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Great Britain, 2007. A deadly plague, known as the “Reaper Virus,” has broken out, killing hundreds of thousands in its wake. In desperation, the British Government evacuates as many survivors as it can out of the infected area, and then builds a wall, preventing the remainder from escaping. Thirty years later, with the wall still up and the victims all but forgotten, the virus breaks out again. The Government decides to send a crack team of operatives, led by Major Eden Sinclair, into the hot zone to investigate the possibility of a cure.

After her divorce, Meg Altman and her daughter Sarah move into an old-fashioned house with one very modern addition: a “panic room” which is virtually impossible to break into, designed for refuge during a home invasion. In their first night in the house a trio of thieves do break in and Meg and Sarah rush into the panic room. However, the intruders are looking for something inside the panic room, and given the recent move the room’s hotline to the police hasn’t been hooked up yet. Worse, Sarah is diabetic and the room doesn’t contain any sugar…