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Lazy stoner Dale Denton has only one reason to visit his equally lazy dealer Saul Silver: to purchase weed, specifically, a rare new strain called Pineapple Express. But when Dale becomes the only witness to a murder by a crooked cop and the city’s most dangerous drug lord, he panics and dumps his roach of Pineapple Express at the scene. Dale now has another reason to visit Saul: to find out if the weed is so rare that it can be traced back to him. And it is. As Dale and Saul run for their lives, they quickly discover that they’re not suffering from weed-fueled paranoia; incredibly, the bad guys really are hot on their trail and trying to figure out the fastest way to kill them both. All aboard the Pineapple Express.

As the film opens on an Oklahoma farm during the depression, two simultaneous visitors literally hit the Wagoneer home: a ruinous dust storm and a convertible crazily driven by Red, the missus’ brother. A roguish country-western musician, he has just been invited to audition for the Grand Ole Opry, his chance of a lifetime to become a success. However, this is way back in Nashville, Red clearly drives terribly, and he’s broke and sick with tuberculosis to boot. Whit, 14, seeing his own chance of a lifetime to avoid “growing up to be a cotton picker all my life,” begs Ma to let him go with Uncle Red as driver and protege. Thus begins a picaresque journey both hilarious and poignant.

L.A. in the early 1930’s: racism, poverty, and disease color the Bunker Hill neighborhood where Arturo Bandini, a lover of men and beasts alike, has arrived from Colorado to write the great Los Angeles novel. After six months and down to his last nickel, he orders a cup of coffee, served by Camilla Lopez, beautiful, self-possessed, and Mexican. Arturo gets advice, encouragement, and an occasional check from H.L. Mencken, so he keeps writing and he keeps seeing Camilla. But, he’s mean to her for no apparent reason, so the relationship sputters. A housekeeper from back East suggests a way out of his jealously and fears. “Camilla Bandini”: is it in the cards?