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After returning from a wedding reception, a couple staying in an isolated vacation house receive a knock on the door in the mid-hours of the night. What ensues is a violent invasion by three strangers, their faces hidden behind masks. The couple find themselves in a violent struggle, in which they go beyond what either of them thought capable in order to survive.

Television reporter Angela Vidal (Carpenter) and her cameraman (Harris) are assigned to spend the night shift with a Los Angeles Fire Station. After a routine 911 call takes them to a small apartment building, they find police officers already on the scene in response to blood curdling screams coming from one of the apartment units. They soon learn that a woman living in the building has been infected by something unknown. After a few of the residents are viciously attacked, they try to escape with the news crew in tow, only to find that the CDC has quarantined the building. Phones, internet, televisions and cell phone access have been cut-off, and officials are not relaying information to those locked inside. When the quarantine is finally lifted, the only evidence of what took place is the news crew’s videotape.

A retired special agent named John Matrix led an elite unit and has left the armed forces to live in a secluded mountain home with his daughter Jenny. But now he is forced out of retirement when his daughter is kidnapped by a band of thugs intent on revenge! Unbeknownst to Matrix, the members of his former unit are being killed one by one. Even though Matrix’ friend General Franklin Kirby gives Matrix armed guards, attackers manage to kidnap Matrix and Jenny. Matrix learns that Bennett, a former member of his Matrix’ unit who was presumed dead has kidnapped him to try to force Matrix to do a political assassination for a man called Arius (who calls himself El Presidente), a warlord formerly bested by Matrix who wishes to lead a military coup in his home country. Since Arius will have Jenny killed if Matrix refuses, Matrix reluctantly accepts the demand.

Jerry, Bill, Mary, and Denise are two couples out on the road in hopes of writing a book on offbeat roadside attractions. When the four meet Captain Spaulding, they learn of the legend of Dr. Satan. When the four take off in search of finding the tree that Dr. Satan was hung from, they pick up hitchhiker Baby. When their car breaks down, Baby invites them into her house. This is where the two couples meet the Firefly family, a murderous clan of bizarre people. As the family attacks the unsuspecting couples, Jerry and his friends try to survive the house of 1000 corpses and it’s dark secrets.

Great Britain, 2007. A deadly plague, known as the “Reaper Virus,” has broken out, killing hundreds of thousands in its wake. In desperation, the British Government evacuates as many survivors as it can out of the infected area, and then builds a wall, preventing the remainder from escaping. Thirty years later, with the wall still up and the victims all but forgotten, the virus breaks out again. The Government decides to send a crack team of operatives, led by Major Eden Sinclair, into the hot zone to investigate the possibility of a cure.